Almost 100 years before Ellis Island, Philadelphia established The Lazaretto Station. It became the point of entry for all ships and passengers arriving during the quarantine season of June through October.
- The Lazaretto is the oldest surviving quarantine hospital in the western hemisphere.
- Maritime quarantine stations were first established in Europe in the 14th century and named "Lazaretto" after St. Lazarus, patron saint of lepers.
- The original lazaretto was built in 1742 on Fisher’s island, but after the Yellow Fever epidemic of 1793 the new Philadelphia Board of Health determined that it was too close to the growing city and provided too much contact with local residents to be effective.
- The new facility was commissioned in 1799 and built on a 10 acre site at Tinicum, about 7 miles downriver from Philadelphia.
- Tinicum was originally the home of the Okehocking tribe of the Leni-Lenape Indians and became the site of the first European settlement in Pennsylvania when Swedish settlers made it their home in 1643.
- The Lazaretto had a 500-bed hospital and administration building plus kitchens, bathhouses, living quarters for hospital staff, bargemen and maintenance workers, houses for the Lazaretto Physician and Quarantine Master, quarters for quarantined visitors and a cemetery. The grounds were beautifully landscaped with fruit trees, shade trees, shrubbery, and manicured lawns.
- Every ship bound for Philadelphia during Quarantine Season was required to stop at the Lazaretto for inspection. The captain had to answer 21 questions about ports of call, nature of cargo, and any sickness of passengers of crew. Every person on board was examined and questioned by a doctor and any sick people were transferred to the hospital. The ship and cargo were examined and bilge water emptied and replaced with clean water. Any evidence of disease led to a quarantine of the entire ship for up to 40 days, although non-contagious cargo could be sent ahead to the city.
- Ships paid a fee for the inspection and were also charged room and board for sick and quarantined passengers with additional charges for laundry. Inspection fees for foreign ships were 25% higher than for American ships.
- Many fever victims died at the Lazaretto, but thanks to good medical care, many more survived and went on to establish families in their adopted country. It has been estimated that 1 in 3 Americans has an ancestor who was cleared for entry at the Lazaretto.
- In 1880, the federal government took over the quarantine function from the states and the Lazaretto was closed in 1895.
- In 1917, the site became the first seaplane base in the US and the Army Signal Corps trained flyers there.
- Tinicum township purchased the property in 2005 and has plans to preserve the site and put its municipal offices there.