- 1 Schroeder's Marble Yard
- 2 Schulkill Hose Company
- 1 Schull, D.J.-Coach Manufacturer
- 1 Schulz, Theodor, 1770-1850
- 1 Schumacher & Ettinger
- 1 Schumann's Tannery
- 1 Schutz, Anton Joseph Friedrich, 1894-1977
- 11 Schuykill Avenue
- 4 Schuylkill Arsenal
- 3 Schuylkill Fishing Company
- 1 Schuylkill Mills
- 226 Schuylkill River
- 112 Schwarzmann, H. J. (Hermann J.)
- 1 Schwarzwaelder Co. (rubberizing textile goods)
- 1 Schweigart Bros. American Dye Works
- 2 Schweitzer, Albert, 1875-1965
- 1 Schwenckfeld, Caspar, 1489-1561
- 10 Schwenkfelders
- 9 Science
- 16 Science museums (buildings)
- 2 Scientific equipment
- 20 Scientific illustrations (images)
- 2 Scientific illustrators
- 2 Scientists
- 1 Scipio, Africanus, ca. 236-183 B.C.
- 4 Scissors
- 3 Scissors & shears
- 1 Scooters
- 3 Scorpio symbols
- 2 Scorpionfishes
- 1 Scorpions
- 8 Scotland
- 2 Scott Bros. (wagon shed & stable)
- 1 Scott Building
- 1 Scott Paper Co.
- 1 Scottish Terriers
- 1 Scovill Manufacturing Company
- 2 Scrap drives
- 4 Scrap metal
- 57 Scrapbooks
